Surgical Treatment for Undifferentiated Pleomorph…

Undifferentiated pleomorphic sarcoma (UPS) is a rare, aggressive soft-tissue cancer that can arise in or beneath the skin, usually as a rapidly growing lump in older adults. Complete surgical removal is the cornerstone of treatment.
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About Surgical Treatment for UPS:

Fast-growing lumps don’t reward patience—with UPS, earlier surgery means less extensive surgery and better outcomes. At Charleston Dermatology, our team evaluates rapidly enlarging nodules with biopsy and appropriate imaging to establish the diagnosis and gauge the tumor’s depth.

Superficial UPS confined to the skin has a notably better outlook than deep tumors, which is why prompt evaluation matters so much. Treatment is built around your tumor. Margin-controlled excision—including Mohs in select superficial cases—removes the cancer with verified clear edges.

We coordinate with surgical, radiation, and medical oncology whenever the tumor’s size or depth calls for a multidisciplinary approach. If something on your skin is growing by the week, don’t wait on it. Schedule a visit now.

Frequently Asked Questions

Diagnosis requires a biopsy, and because UPS is defined by what its cells don’t resemble, pathologists use special stains to rule out other cancers first. Imaging (ultrasound or MRI) often follows to map how deep the tumor extends, which shapes the surgical plan and prognosis.

The goal is wide, complete removal with margins confirmed free of tumor. Superficial tumors limited to the skin can often be cleared with margin-controlled excision in the office setting, while deeper or larger tumors are removed in coordination with surgical oncology, sometimes with radiation before or after surgery.

It depends heavily on depth and size. Superficial UPS confined to the skin, completely removed, has a favorable prognosis with low rates of spread. Deeper, larger tumors carry more risk and warrant multidisciplinary care. Across the board, early detection and complete first-time removal are the two factors that most improve outcomes.

Our Specialists

Adam Sperduto, MD
Roger Sullivan, MD
Lee Yarbrough, MD
Ashley Allen, MD
Megan Hohenberger, MD