Mohs Surgery for Dermatofibrosarcoma Protuberans

Dermatofibrosarcoma protuberans (DFSP) is a rare skin sarcoma known for sending root-like extensions far beyond its visible edges. That growth pattern makes Mohs micrographic surgery — which tracks and clears every margin — an ideal treatment.
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About Mohs Surgery for DFSP:

DFSP’s biggest danger isn’t spread to other organs, which is rare—it’s coming back after incomplete removal. The tumor’s tentacle-like projections are invisible to the naked eye.

At Charleston Dermatology, our surgeons treat DFSP with Mohs surgery precisely because of those projections. By examining 100% of the margin under the microscope and removing additional tissue only where tumor remains, Mohs traces each extension to its end. Published recurrence rates with Mohs are around 1–3%, compared with roughly 7% or higher for wide excision—a meaningful difference for a tumor this persistent.

After clear margins are confirmed, the site is repaired, and a long-term follow-up schedule watches for any recurrence. Schedule a consultation and we’ll build your surgical plan.

Frequently Asked Questions

Because DFSP infiltrates surrounding tissue in thin, irregular projections that standard margins can miss. Mohs examines the entire margin during surgery, so every extension is followed and removed. Studies consistently show lower recurrence rates with Mohs than with conventional wide excision, and less healthy tissue is sacrificed along the way.

DFSP surgeries can take longer than a typical Mohs case because the tumor’s extensions may require several stages to clear. The procedure is done under local anesthetic, and larger defects occasionally need staged repair or coordination with reconstructive colleagues. Your surgeon will walk you through the likely scope before surgery day.

Follow-up is long-term: DFSP can recur years after treatment, so periodic skin exams of the surgical site continue for at least five years, often longer. Recurrence after clear Mohs margins is uncommon, and spread beyond the skin is rare. Most patients treated with complete removal do extremely well.

Our Specialists

Adam Sperduto, MD
Roger Sullivan, MD
Lee Yarbrough, MD
Ashley Allen, MD
Megan Hohenberger, MD