About Undifferentiated Pleomorphic Sarcoma Treatment Services
A lump that’s growing quickly—especially one that’s firm, deep, or larger than a golf ball—needs prompt evaluation, not a wait-and-see approach.
At Charleston Dermatology, our physicians and providers evaluate concerning growths with examination and biopsy. Because UPS is diagnosed by ruling out other tumors under the microscope, accurate pathology is essential, and imaging helps determine how deep the tumor extends.
Treatment is built around your diagnosis and is coordinated with a multidisciplinary team, typically surgical oncology, and sometimes radiation or medical oncology. Complete surgical removal offers the best outcomes, and earlier detection means less extensive treatment. Schedule a visit promptly for any rapidly growing lump—timing matters here.
Frequently Asked Questions
What is undifferentiated pleomorphic sarcoma?
UPS is a cancer of connective (soft) tissue whose cells are so abnormal that they don’t resemble any specific normal tissue—that’s what “undifferentiated” means. When it involves the skin, it typically appears as a firm, rapidly growing nodule, often on the limbs or on sun-damaged skin of the head and neck in older adults.
What causes UPS?
In most cases, no cause is found. Known risk factors include prior radiation therapy, chronic lymphedema, significant sun damage for superficial tumors, and a weakened immune system. It is not inherited in most families and is not contagious.
How is UPS treated?
Surgery to remove the tumor completely with clear margins is the foundation of treatment. Depending on the tumor’s size, depth, and location, radiation before or after surgery may be recommended, and advanced cases may involve medical oncology. Superficial tumors confined to the skin generally have a better outlook than deep ones, which is another reason early evaluation of any fast-growing lump is so important.