B-Cell Lymphoma

Primary cutaneous B-cell lymphoma is a rare form of non-Hodgkin lymphoma that starts in the skin rather than the lymph nodes. It typically appears as firm, painless, pink to purple bumps or nodules, and most types grow slowly.
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About B-Cell Lymphoma Treatment Services

A diagnosis with the word “lymphoma” in it is frightening, but most B-cell lymphomas of the skin are slow-growing and highly treatable.

At Charleston Dermatology, our physicians and providers begin with a careful exam and skin biopsy to identify the exact type of lymphoma, since the subtype determines both the outlook and the treatment. We coordinate closely with oncology when additional evaluation or care is needed.

Treatment plans are built around your specific diagnosis and may include radiation therapy, injections into the lesions, surgical removal, or medication for more widespread disease. Many patients do very well with treatment. Schedule a visit and let our team guide you through the next steps.

Frequently Asked Questions

It’s a cancer of B-lymphocytes (a type of white blood cell) that develops in the skin. The most common types—follicle center lymphoma and marginal zone lymphoma—are indolent, meaning they grow slowly and rarely spread beyond the skin. A less common type, diffuse large B-cell lymphoma, leg type, is more aggressive and needs prompter treatment.

In most cases the cause is unknown. It is not contagious and is not caused by anything you did. It occurs most often in middle-aged and older adults, and some research has explored links to chronic immune stimulation and certain infections, though no single cause has been confirmed.

Treatment depends on the subtype and how much skin is involved. Slow-growing types confined to one area often respond very well to radiation therapy or removal, while more widespread or aggressive disease may be treated with medications such as rituximab in coordination with an oncologist. Regular follow-up is part of every plan.

Our Specialists

Adam Sperduto, MD
Roger Sullivan, MD
Lee Yarbrough, MD
Ashley Allen, MD
Megan Hohenberger, MD